姓名 |
李广宇 |
性别 |
男 |
民族 |
满 |
|
籍贯 |
吉林白山 |
出生年月 |
1982年12月 |
学位 |
博士 |
|
职务职称 |
副教授 |
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联系电话 |
02787282113 |
电子邮箱 |
liguangyu@mail.hzau.edu.cn |
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办公地点 |
华中农业大学水产学院503 |
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研究方向 |
主要从事环境污染物对鱼类及哺乳动物的致毒效应,重点关注环境污染物的胚胎发育毒性及神经毒性,利用转录组、蛋白组及代谢组学手段努力发掘生物标志物,建立预警诊断机制。同时也关注环境因子对渔业资源的影响。 |
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学习经历 |
2005/09 – 2010/06,中国科学院,水生生物研究所,博士(硕博连读) 2001/09 – 2005/06,华中师范大学,生命科学学院,学士 |
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工作经历 |
2012/12 – 至今,华中农业大学,水产学院,副教授/硕士生导师 2010/07 – 2012/12,华中农业大学,水产学院,讲师 |
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讲授课程 |
基础生物化学 基础生物化学实验 |
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主要兼职 |
Sci杂志Toxicology Letter审稿人;Environmental Toxicology审稿人;Chemosphere 审稿人;Journal of Applied Toxicology审稿人 |
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主要成果 |
科研成果 [1] Li GY, Yan W, Qiao Q, Chen J, Cai F, He Y, Zhang X*. Global effects of subchronic treatment of microcystin-LR on rat splenetic protein levels. J. Proteomics 77: 383-393. 2012. [IF 5.07] [2] Li GY, Cai F, Yan W, Li CR, Wang JH*. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicol. Sci. 127(2): 485-495. 2012. [IF 5.09] [3] Liu CS, Yan W , Zhou BS, Guo YY, Liu HL, Yu HX, Giesy JP, Wang JH, Li GY*, Zhang XW*. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquat. Toxicol. 118: 108-115. 2012. [IF 3.72] (共同通讯作者) [4] Yan W, Zhou Y, Yang J, Wang JH, Chen J*, Li GY*. Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae. Chemosphere 87(11): 1301-1307. 2012. [IF 3.15] (共同通讯作者) [5] Li GY, Chen J, Xie P*, Jiang Y, Wu LY, Zhang XZ. Protein profiles in zebrafish (Danio rerio) embryos exposed to microcystin-LR. Proteomics 11:2003-2018. 2011. [IF 4.82] [6] Li GY, Yan W, Cai F, He Y, Chen N, Wang JH*. Spatial learning and memory impairment and pathological change in rats induced by acute exposure to microcystin-LR. Environ. Toxicol. Doi/10.1002/tox.21754. 2013. [IF 2.40] [7] Li GY, Shen D, Liang XF*, He Y, He S. Effects of malachite Green on the mRNA expression of detoxification-related genes in Nile tilapia (Oreochromis niloticus) and other major Chinese freshwater fishes. Environ. Toxicol. Doi/10.1002/tox.20706. 2013. [IF 2.40] (共同第一作者) [8] Li GY, Xie P*, Li HY, Hao L, Xiong Q, Qiu T. Acute effects of microcystins on the transcription of 14 glutathione S-transferase isoforms in Wistar rat. Environ. Toxicol. 26:187-194. 2011. [IF 1.83] [9] Li GY, Xie P*, Li HY, Hao L, Xiong Q, Qiu T, Liu Y. Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis. Environ. Toxicol. 26:111-117. 2011. [IF 1.83] [10] Li GY, Xie P*, Li HY, Chen J, Hao L, Xiong Q. Quantitative profiling of mRNA expression of glutathione S-transferase superfamily genes in various tissues of bighead carp (Aristichthys nobilis). J. Biochem. Mol. Toxicol. 24:250-259. 2010. [IF 1.96] [11] Li GY, Xie P*, Fu J, Hao L, Xiong Q, Li HY. Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish. Aquat. Toxicol. 88:75-80. 2008. [IF 3.52 ] [12] He J, Chen J, Wu L, Li GY, Xie P*. Metabolic response to oral microcystin-LR exposure in the rat by NMR-based metabonomic study. J. Proteome Res. 11:5934-5946. 2013. [IF 5.46] [13] Zhao SJ, Xie P*, Li GY, Chen J, Cai Y, Xiong Q, Zhao YY. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Proteomics 12:300-312. 2011. [IF 4.82] [14] Cheng WX, Liang XF*, Shen D, Zhou Q, He Y, He S. Li GY. Seasonal variation of gut Cyanophyta contents and liver GST expression of mud carp (Cirrhina molitorella) and Nile tilapia (Oreochromis niloticus) in the tropical Xiangang Reservoir ( [15] Wang JH, Shen D, Liang XF*, Li GY, He Y, He S. In situ studies on the seasonal variation of gut cyanophyta contens and liver GST expression of silver carp (Hypophthalmichathys molitrix) and grass carp (ctenopharyngodon idella). Fresen. Environ. Bulle. 20:3053-3058. 2011. [IF 0.72] [16] Xiong Q, Xie P*, Li HY, Hao L, Li GY, Qiu T, Liu Y. Acute effects of microcystins exposure on the transcription of antioxidant enzyme genes in three organs (liver, kidney, and testis) of male Wistar rats. J. Biochem. Mol. Toxicol. 24:361-367. 2010. [IF 1.96] [17] Xiong Q, Xie P*, Li HY, Hao L, Li GY, Qiu T, Liu Y. Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins. Toxicon 54:1-7. 2010. [IF 2.12] [18] Liu Y, Xie P*, Qiu T, Li HY, Li GY, Hao L, Xiong Q. Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis. Environ. Toxicol. 25:9-17. 2010. [IF 1.83] [19] Hao L, Xie P*, Li HY, Li GY, Xiong Q, Wang Q, Qiu T, Liu Y. Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats. Toxicon 55:1378-1386. 2010. [IF 2.12] [20] Qiu T, Xie P*, Liu Y, Li GY, Hao L. Experimental studies on the cardiotoxic effects of microcystins in rat: possibly a new contributing factor to circulatory insufficiency in human microcystin intoxication. Toxicology 257:86-94. 2009. [IF 3.29] [21] Li HY, Xie P*, Li GY, Hao L, Xiong Q. In vivo study on the effects of microcystins extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins. Toxicon 53:169-175. 2009. [IF 2.12] [22] Hao L, Xie P*, Fu J, Li GY, Xiong Q, Li HY. The effect of cyanobacterial crude extract on the transcription of GST mu, GST kappa and GST rho in different organs of goldfish (Carassius auratus). Aquat. Toxicol. 90:1-7. 2008. [IF 3.52] |
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近五年 在研项目 |
[1] 国家自然科学基金《微囊藻毒素的母体传递效应对斑马鱼子代胚胎发育的影响》(31200402,2013.1-2015.12) [2] 教育部新教师基金《环境浓度微囊藻毒素暴露诱发斑马鱼子代胚胎发育毒性的分子机制》(20120146120008,2013.1-2014.12) [3] 湖北省自然科学基金《微囊藻毒素诱发斑马鱼胚胎细胞凋亡的分子机制研究》(2011CDB151,2011.1-2012.12) |
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获奖情况 |
2011-2012年水产学院“教书育人奖” |